Details of Nystagmus Working Group Meeting 5 (2026-06-18)

Date/time

Tuesday 18th June 2026. Chaired by Helena Lee (University of Southampton). Vice-chair: Rebecca McLean (University of Leicester).

Agenda

  • Welcome and Apologies
  • Committee Membership Updates
    • New members joining the subcommittee
  • Minutes and Actions from Previous Meeting
    • Review and approval of minutes (circulated in advance)
    • Review of completed and outstanding action points
  • Fixation Guideline Development
    • Technology requirements review
    • Overview of consolidated evidence base search (circulated in advance)
    • Discussion of methodological approach to synthesis
    • Consideration of clinical applicability and consensus areas
    • Identification of areas requiring further evidence or expert input
  • Next Steps for Guideline Development
    • Allocation of drafting responsibilities
    • Timelines for next iteration
    • Agreement on review process
  • Any Other Business

Meeting recording

Attendees

  • Helena Lee
  • Matt J Dunn
  • James Self
  • Larry Abel
  • Fiona Bríd Mulvey
  • Amanda Douglass
  • Rebecca J. McLean
  • Siyuan Chen
  • Audrey Bonnan
  • Onyeka Amiebenomo
  • Herman Talsma
  • Andreas Sprenger
  • Sian Handley
  • Ruth Hamilton

Apologies

  • Herbert Jägle
  • Gemma Arblaster
  • Artur Cideciyan
  • Fatima Shawkat
  • Mervyn Thomas
  • Omar Mahroo
  • Susanna Martinez
  • Rasha Moustafa

Notes

1. Welcome and Apologies


2. Minutes of Previous Meeting

Previous minutes approved without amendment.


3. Review of Literature to Inform Technology Requirements

3.1 Guideline drafting (Lee)

  • Introductory paragraph on physiology of ocular fixation drafted and shared.
  • Agreed:
    • Keep physiology section brief and clinically oriented.
    • Seek input from Susanna Martinez for refinement.

3.2 Literature review (Mulvey & Abel)

  • Substantial progress made with multiple iterations.
  • Formal presentation deferred to later agenda item.

3.3 Standards framework (Dunn)

  • Draft structure presented linking:
    • Core eye movement tests
    • Condition-specific applications
    • General protocols (data processing, storage, normative datasets)

Key discussion points:

  • Core tests underpin condition-specific protocols.
  • Avoid duplication across disease-specific sections.
  • Distinguish:
    • Presentations vs diagnoses (important shift).
  • Need flexibility for:
    • Rare conditions
    • Neurological presentations
  • Consider inclusion of:
    • Visual search tests
    • Vestibular/balance assessments

Conclusion:

  • Framework valuable but requires further group refinement.

3.4 Evidence allocation & tables (Lee & McLean)

  • Parameter tables completed and evidence review tasks distributed.
  • Paediatric compliance statement pending completion.

4. Technology Requirements (Mulvey & Abel)

Summary of work

  • Comprehensive review of:
    • Sampling rates
    • Spatial/temporal precision
    • Hardware limitations
    • Existing standards (e.g., Bárány Society)
  • Summary table of quantitative thresholds developed.

Key conclusions

  • Minimum technical specifications should support quantitative analysis.
  • Clinical judgement required for qualitative use.
  • One standard (rather than separate research/clinical specs) preferred.

Discussion highlights

  • Balance needed:
    • High-quality data vs clinical feasibility
  • Hardware vs software gap:
    • Hardware is adequate
    • Automated quantitative analysis remains limited
  • Emerging technologies (e.g. VR headsets) may lack validated performance thresholds

Actions

  • Reviewers to provide feedback:
    • Matt J Dunn (confirmed)
    • Helena Lee, Rebecca J. McLean, Andreas Sprenger, Siyuan Chen (volunteered)
  • Fiona Mulvey to add reviewers via Overleaf.

5. Fixation Guideline Development – Evidence Review

5.1 Patient positioning & setup

  • Screen distance widely variable (40–70 cm observed).
  • Need to consider convergence effects
  • No consensus → requires consensus exercise.
  • Head stabilisation:
    • Chin + forehead rest common for desktop systems.
    • Considerations for head-mounted trackers (slippage, drift).

5.2 Room lighting

  • Key principle: lighting consistency is critical.
  • Conflicting factors:
    • Device-specific optimisation
    • Standardisation across centres
  • Some neurological conditions affected by lighting.
  • Existing audiology guidance (dark environment) must be acknowledged.

Action: Consensus exercise required.


5.3 Target properties

  • Shape/detail affects fixation variability.
  • Recommendation:
    • ~1° visual angle as standard baseline
    • Adjust for clinical need
  • Technical insight:
    • Odd pixel number preferred (clear centre point).

5.4 Target location

  • Central fixation most commonly used.
  • Eccentric targets required for:
    • Nystagmus characterisation
    • Gaze-dependent effects

➡ Central = baseline; eccentric = condition – specific.


5.5 Contrast

  • High contrast (>80% Michelson) widely supported in literature.
  • Lower contrast may reduce data quality.

5.6 Duration of testing

  • Strong agreement: depends on clinical question.
  • Evidence:
    • Fixation degrades with prolonged testing
    • Suggested upper bound ≈ 4–5 minutes per continuous task
  • Prefer:
    • Simple upper-limit guidance rather than detailed prescriptions.

5.7 Rest breaks

  • Essential to maintain data quality.
  • Should include:
    • Breaks between trials
    • Recalibration where needed

5.8 Monitoring during testing

  • Key aspects to monitor:
    • Real-time data quality
    • Attention/fixation engagement
    • Tracking integrity (pupil/corneal reflection)

5.9 Outstanding Evidence to be submitted

  • Sian Handley and Mervyn Thomas requested a short extension to complete their section (Visual correction used – or not & Binocular/monocular)
  • No update received for: “Duration of target – default 30sec, minimum 10sec, 7mins for PAN” – assigned to Frank Proudlock (Omar Mahroo has advised cannot contribute to this as does not have expertise in EMR – is present in capacity as EDT expert)

6. Overall Conclusions

  • Many parameters are:
    • Evidence-informed but not standardised
    • Context-dependent
  • Strong recurring themes:
    • Need for standardisation vs flexibility balance
    • Importance of consistency across centres
    • Distinction between fixation vs nystagmus protocols

Action Log

ActionOwnerNotesStatus
Refine physiology section and share with Susanna MartinezHelena LeeSend draft for expert inputOpen
Review technology requirements manuscriptMatt J Dunn, Rebecca McLean, Andres, Siyuan ChenProvide feedback via OverleafIn progress
Consolidate evidence tables into draft guidelineHelena Lee & Rebecca McLeanPrepare document for circulationOpen
Arrange consensus exercise (distance, lighting, etc.)Helena Lee & Rebecca McLeanDevelop structured feedback toolOpen
Complete outstanding guideline components evidence gatheringSian Handley, Mervyn Thomas, Frank ProudlockComplete evidence synthesis and submit to the group for feedbackOpen
Circulate draft for group feedbackHelena LeeEnsure fixation scope clearly definedOpen
Schedule follow-up meetingHelena LeeAfter feedback receivedPlanned